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我院消化内科聘请美国耶鲁大学肝病中心蔡仕英研究员为客座教授
点击:次      日期:2015-07-28 16:44      打印
  7月13日下午,美国耶鲁大学肝病研究所蔡仕英研究员受聘我院客座教授仪式在教学楼五楼第二会议室举行。消化内科陈文生主任为蔡仕英研究员颁发了证书。仪式后,蔡仕英研究员做了精彩的学术讲座。
    蔡仕英教授现任美国耶鲁大学医学院肝病中心研究员,耶鲁大学肝病中心分子与细胞研究所副主任,Mount Desert Island Biological Laboratory (MDIBL)成员。曾因其在DARPA(Defense Advanced Research Projects Agency)项目中的出色研究而获得“杰出贡献奖”。蔡教授长期致力于胆汁淤积的分子机制的研究,获得过美国肝病学会、耶鲁大学肝脏中心等的多项资助,已在包括Hepatology、Gastroenterology、J Bio Chem、 Acta PharmacolSin、Am J Gastrointest Liver Physiol等国际顶级专业学术期刊发表论著30余篇,前期已与消化科进行过多年的合作研究工作。

    受聘仪式上,陈文生主任介绍了蔡仕英教授的基本情况。随后,蔡教授以“The Mechanism of Bile Acids Induced Liver Injury”为主题做了精彩的学术报告,详细讲述了胆汁酸、炎症因子及肝损伤之间的关系,并就目前肝病研究的前沿进展做了报告。讲座结束后,与会人员就“胆汁酸是如何刺激肝细胞产生炎症因子”、“胆汁淤积动物模型的构建”等问题进行了热烈的互动交流。最后,蔡教授表示将加强与西南医院全军消化病研究所的科研合作,互利双赢,为学科发展和我院建设作出更多的贡献。

    蔡仕英教授近年来发表的代表性论著:


 1.Cai SY, Mennone A, Soroka CJ, Boyer JL. All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice. J Pharmacol Exp Ther. 2014 Apr;349(1):94-8.

2.  Cai SY, Mennone A, Soroka CJ, Boyer JL. Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15;306(8):G670-6.

3.  Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology. 2013 Jun;57(6):2418-26.

4.  Lionarons DA, Boyer JL, Cai SY. Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2). J Lipid Res. 2012 Aug;53(8):1535-42.

5.  He H, Mennone A, Boyer JL, Cai SY. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. Hepatology. 2011 Feb;53(2):548-57.

6.  Cai SY, He H, Nguyen T, Mennone A, Boyer JL. Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms. J Lipid Res. 2010 Aug;51(8):2265-74.

7.  Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.Hepatology. 2009 Nov;50(5):1588-96.

8.  Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology. 2009 Mar;136(3):1060-9.

9.  Cai SY, Xiong L, Wray CG, Ballatori N, Boyer JL. The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1400-9.

10. Cai SY, Babbitt RW, Marchesi VT. A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2828-33